The fruit is also a rich source of beta carotene and vitamin C. Mango contains a glycoside called mangiferin which possesses anti-viral, anti-microbial, anti-atherosclerotic, and anti-diabetic properties. Mango constitutes half of the whole fruit production in India. In India the fruit is referred to as the “fruit of the gods”. Mango has been cultivated for approximately 6000 years. Other representatives of the same family are pistachios and cashew nuts. The plant belongs to the Anacardiaceae family. Mango (Latin: Mangifera indica), called the “king of fruit”, is one of the most commonly grown exotic fruits. Considering the anaphylactic reaction the patient was instructed to carry a rescue set composed of an adrenaline autosyringe, steroids, and antihistamines. The elimination diet removing allergens the patient was allergic to was recommended. During in vitro diagnostic procedures we found an elevated concentration of IgE specific to several food allergens (including celery, peppers, carrot, banana, peach, apple, shrimp). Acute urticarial in this case is a manifestation of IgE-mediated food allergy. ConclusionsĪn anaphylactic reaction to consumed mango, resulting from cross-allergy with mugwort Art v 1 was diagnosed in the patient. We also performed the IgE inhibition test using both mango extract and ImmunoCap matrix and confirmed a cross-reaction with Art v 1 in the pathogenesis of symptoms observed in the patient. The ImmunoCap ISAC test demonstrated a high level of specific IgE rPhl p 1 (timothy grass) and Art v 1 (mugwort). The level of specific IgE was increased for allergens of mugwort, grass, celery, pepper, carrot, mango, banana, peach, and apple. Skin prick tests (SPT) were positive for allergens of grass 7 mm weeds 8 mm cat’s fur 5 mm mugwort 6 mm. In order to confirm the occurence of a cross-reaction between mugwort and mango allergens, we performed the inhibition test of IgE specific for mugwort using a mango allergen extract and ImmunoCap matrix. Diagnostics was extended by determining the levels of IgE specific for allergen components, using the ImmunoCap ISAC method. Additionally, an interview revealed that the patient was experiencing symptoms of the oral allergy syndrome after ingesting various fruit and vegetables, especially during late summer and fall. The patient also experienced symptoms of recurrent, generalized urticaria in connection with consumption of various types of food, especially complex dishes containing many different ingredients. The diagnostics involved skin tests with a set of inhalatory and food allergens, including native skin tests. Within several minutes the patient developed a generalised urticaria, followed by facial oedema, strong stomach pain and watery diarrhoea. The most severe allergic reaction in the patient’s life occurred after eating a mango fruit. Case studyĪ female patient, 30 years old, was admitted in February 2017 because of recurrent allergic reactions following consumption of various foods. A panallergen with a structure similar to mugwort defensin (Art v 1) which cross-reacts with celery, carrot, peanuts, pepper, aniseed, and caraway has been previously described. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions between mango and pear, apple, and peach. The antigenic composition of the fruit is not fully known.
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